Medical Tourism

Beyond TMS: Exploring Alternative Treatments for Treatment-Resistant Depression

Medical Tourism

Treatment-resistant depression (TRD) presents a significant challenge for patients and healthcare providers. With conventional treatments like medication and psychotherapy often falling short, many individuals turn to Transcranial Magnetic Stimulation (TMS) as a non-invasive treatment option. However, TMS may not work for everyone, and some patients may need to explore other alternatives to find relief from their symptoms. In this article, we will discuss a range of alternative treatments for TRD, highlighting the innovative work of Dr. Steve Best at The Neuroscience Center.

When TMS Doesn't Work: Understanding the Need for Alternative Treatments

TMS is a non-invasive treatment that uses magnetic pulses to stimulate specific areas of the brain associated with depression. While TMS can be effective for many patients, some individuals may not experience significant improvement in their symptoms. In these cases, it is crucial to explore alternative treatments to find the most effective approach to managing TRD.

Alternative Treatments for Treatment-Resistant Depression

For patients who have not experienced success with TMS, there are several other innovative treatments and therapies available. Some of these include:

Deep Transcranial Magnetic Stimulation (Deep TMS)

Deep TMS is a more advanced form of TMS that penetrates deeper into the brain, allowing for targeted stimulation of areas that may be less responsive to traditional TMS. By reaching these deeper brain regions, Deep TMS can potentially offer better results for patients with TRD. Dr. Steve Best and The Neuroscience Center are at the forefront of utilizing Deep TMS in the treatment of refractory depression.

Ketamine Therapy

Ketamine, a medication traditionally used as an anesthetic, has shown promise as a rapid-acting treatment for TRD. Unlike conventional antidepressants, ketamine works by modulating glutamate, a neurotransmitter that plays a crucial role in neural plasticity and synaptic connections. Studies have shown that a single dose of intravenous ketamine can produce significant improvements in depressive symptoms within hours. Dr. Best and The Neuroscience Center offer ketamine therapy as an innovative treatment option for TRD patients.

Electroconvulsive Therapy (ECT)

Electroconvulsive therapy (ECT) is a well-established treatment for severe depression that involves the application of brief electrical pulses to the brain while the patient is under general anesthesia. Although ECT has been associated with stigma and misconceptions in the past, it is a safe and effective treatment option for many patients with TRD who have not responded to other treatments, including TMS.

Vagus Nerve Stimulation (VNS)

Vagus nerve stimulation (VNS) is a surgical procedure that involves implanting a device under the skin on the chest that sends electrical pulses to the vagus nerve, which is responsible for regulating mood and other bodily functions. VNS has been approved by the FDA for treating TRD and has shown promise in reducing depressive symptoms in patients who have not responded to other treatments. Dr. Best and The Neuroscience Center are experienced in utilizing VNS as an alternative therapy for TRD patients.

Esketamine Nasal Spray

Esketamine is a derivative of ketamine that has been approved by the FDA for use as a nasal spray in conjunction with an oral antidepressant for treating TRD. It has a rapid onset of action, with some patients experiencing improvement in depressive symptoms within hours of administration. Esketamine nasal spray can be a valuable treatment option for patients who have not found relief with TMS or other therapies.


While some patients with TRD may not respond well to conventional psychotherapy, exploring different therapeutic approaches can be beneficial. Evidence-based therapies such as cognitive-behavioral therapy (CBT), dialectical behavior therapy (DBT), and acceptance and commitment therapy (ACT) can help patients develop coping strategies, build resilience, and address underlying issues contributing to their depression.


Neurofeedback is a therapy that involves training the brain to self-regulate its electrical activity, with the goal of improving brain function and alleviating symptoms of various mental health conditions. By providing real-time feedback on brainwave patterns, patients learn to modify their brain activity and, in turn, improve their mental health. Dr. Best incorporates neurofeedback into his integrative approach to treating TRD at The Neuroscience Center.

Holistic Mental Health and Integrative Psychiatry

For patients struggling with TRD, adopting a holistic approach to mental health can be beneficial. This approach includes integrating conventional treatments with alternative therapies, focusing on lifestyle factors such as diet, exercise, and sleep, and addressing underlying medical conditions that may contribute to depression. Dr. Steve Best at The Neuroscience Center specializes in personalized medicine and integrative psychiatry, tailoring treatment plans to each patient's unique needs and circumstances.

The Benefits of Seeking Expert Care Abroad

For patients struggling with TRD, medical tourism can provide access to expert care and innovative therapies that may not be readily available in their home country. By seeking treatment abroad, patients can:

  1. Access cutting-edge treatments and therapies.
  2. Receive care from world-renowned experts and specialists.
  3. Potentially reduce healthcare costs due to lower treatment expenses in certain countries.
  4. Combine healthcare with travel, offering opportunities for relaxation and rejuvenation.

For individuals with treatment-resistant depression who have not experienced success with TMS, it is essential to explore alternative treatments to find relief from their symptoms. Dr. Steve Best and The Neuroscience Center offer a range of innovative therapies, including Deep TMS, ketamine therapy, ECT, VNS, esketamine nasal spray, psychotherapy, neurofeedback, and a holistic approach to mental health. By considering medical tourism and researching expert care options, patients can make informed decisions and take an active role in their path to recovery. To learn more about Dr. Best and The Neuroscience Center, visit

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